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KMID : 0360319950270020253
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 2 p.253 ~ p.264
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Prognostic Significance of Tumor Angiogenesis, Metastasis Regulation Gene Protein(NDP-K/nm23)and Histone mRNA Expression in Breast Cancer
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Abstract
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Tumor angiogenesis and expression of metastasis regulation gene protein(nm23) and histone mRNA were eveluated in 42 breast cancers to assess their roles in prognosis. Tumor angiogenesis was studied by measuring the FVIIIRA-positive endothelial
cells,
and nm23 protein expression by immunohistochemical staining. Histone mRNA poisitive cells were examined by non-isotopic in situ hybridization. The results were analyzed according to the patient's age, tumor size, presence or absence of lymph node
metastais and DNA ploidy.
DNA aneuploidy was found in 28 of 38 (74%) and Factor VIIIRA-positive endothelial cells were found within and around the invasive carcinoma and periductal stoma in intraductal carcinoma. Tumor angiogenesis was more active in primary tumors than
in
metastatic lesions. nm23 protein expression was strong in normal parenchyme, but it was variable in stainability and extents according to the areas. The intraductal component showed stronger staining than invasive carcinoma in nm23 protein
expression.
Histone mRNA positive cells were found in both normal and malignant epithelial cells, but more frequent in metastatic lesion than in primary tumor. Tumor angiogenesis and loss of nm23 protein were associated with the presence of metastatic node
and
large size of primary tumor(≥3cm). The expression of histone mRNA was only associated with poor differentiation of tumor, but not with S-phase fraction of cell cycle study.
From this study, it is concluded that tumor angiogenesis and expression of nm23 protein could be used as prognostic indicators in breast cancers, but histone mRNA expression had the limited value.
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